Vilagletistat
ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC50 of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD) [1][2].
Product Specifications
CAS Number
[1542132-88-6]
Product Name Alternative
ZED-1227
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zed-1227.html
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(OC)/C=C/CC[C@H](NC(C1=CN=CN1C)=O)C(NC2=CC=CN(CC(NCC(CC)CC)=O)C2=O)=O
Molecular Formula
C26H36N6O6
Molecular Weight
528.60
Precautions
H301, H311, H331, H341
References & Citations
[1]Manu Encalada, et al. The Oral Transglutaminase 2 (TG2) Inhibitor Zed1227 Blocks TG2 Activity in a Mouse Model of Intestinal Inflammation. Gastroenterology. 154 (6) :S-490.|[2]Christian Büchold, et al. Pyridinone derivatives as tissue transglutaminase inhibitors. WO2014012858A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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