Human Galectin-3 Protein, His tag (Animal-Free)

Galectin-3 (Gal-3) is one of the lectin family members, which is the only chimera‐type galectin, containing one carbohydrate recognition domain (CRD) connected to a long, flexible N‐terminal domain. The C‐terminal CRD is responsible for β-galactoside binding, and the N‐terminal domain is essential for its multimerization, and interaction with other intracellular proteins. Galectin-3 is predominantly presented in the cytoplasm and expressed on the cell surface, and then often secreted into biological fluids, such as serum and urine. Numerous studies have indicated that galectin-3 plays a crucial role in cell proliferation, apoptosis, gene expression, immune surveillance, inflammation, fibrosis, and host defense.