Rp-8-Br-cGMPS
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from the cell[1][2].
Product Specifications
CAS Number
150418-07-8
Product Name Alternative
Rp-8-bromo-Cyclic GMPS
UNSPSC
12352005
Target
Calcium Channel; HCN Channel; PKG
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/rp-8-br-cgmps.html
Smiles
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@]4(S)=O)O3)C(Br)=N2)NC(N)=N1
Molecular Formula
C10H11BrN5O6PS
Molecular Weight
440.17
References & Citations
[1]Rashatwar SS, et, al. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1987 Aug;84 (16) :5685-9.|[2]Barnstable CJ, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochem Int. 2004 Nov;45 (6) :875-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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