TLQP-62 (mouse, rat)

TLQP-62 (mouse, rat) is a secreted C-terminal peptide derived from the protein VGF. It activates the BDNF-TrkB signaling pathway, inducing acute and transient phosphorylation of TrkB receptors and downstream phosphorylation of CREB (Ser133) . TLQP-62 effectively enhances long-term fear memory formation in wild-type mice and can reverse memory deficits in VGF heterozygous knockout mice. This compound is useful for researching memory-related neurological diseases, such as Alzheimer's disease and frontotemporal dementia.