HO-3867
HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor activity.
Product Specifications
CAS Number
1172133-28-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HO-3867.html
Concentration
10mM
Purity
99.67
Solubility
DMSO : ≥ 32 mg/mL
Smiles
O=C1/C(CN(CC2=CC(C)(C)N(O)C2(C)C)C/C1=C\C3=CC=C(F)C=C3)=C/C4=CC=C(F)C=C4
Molecular Formula
C28H30F2N2O2
Molecular Weight
464.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Rath KS et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 2014 Apr 15;74 (8) :2316-27.|[2]Tierney BJ et al. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer Biol Ther. 2012 Jul;13 (9) :766-75|[3]Hu Y, et al. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anticancer Drugs. 2017 Apr;28 (4) :392-400.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Frequently Asked Questions
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