HO-3867

HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor activity.

Product Specifications

CAS Number

[1172133-28-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; STAT

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HO-3867.html

Concentration

10mM

Purity

99.67

Solubility

DMSO : ≥ 32 mg/mL

Smiles

O=C1/C(CN(CC2=CC(C)(C)N(O)C2(C)C)C/C1=C\C3=CC=C(F)C=C3)=C/C4=CC=C(F)C=C4

Molecular Formula

C28H30F2N2O2

Molecular Weight

464.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Rath KS et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 2014 Apr 15;74 (8) :2316-27.|[2]Tierney BJ et al. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer Biol Ther. 2012 Jul;13 (9) :766-75|[3]Hu Y, et al. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anticancer Drugs. 2017 Apr;28 (4) :392-400.