TAT-PiET-PROTAC

TAT-PiET-PROTAC is a TAT-PiET modified by a proteolysis targeting chimera (PROTAC) . TAT-PiET is a cell-penetrating peptide that targets the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC disrupts the interaction between BRD4 and the oncogene JMJD6 in breast cancer, effectively inhibiting the growth of these cancer cells. Additionally, it combats endocrine resistance in ERα-positive breast cancer cells, making it a promising breast cancer inhibitor. TAT-PiET-PROTAC is also utilized in the synthesis/research of radiolabeled conjugate drugs (RDC) .