AP1867-3- (aminoethoxy)
AP1867-3- (aminoethoxy), the AP1867 based moiety, is a synthetic ligand for FKBP. AP1867-3- (aminoethoxy) can be used in the synthesis of PROTAC FKBP12 F36V degrader[1].
Product Specifications
CAS Number
[2127390-15-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
FKBP; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ap1867-3-methoxyethylamine.html
Purity
98.60
Solubility
DMSO : 240 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN)=C3)CCC4=CC=C(OC)C(OC)=C4
Molecular Formula
C38H50N2O9
Molecular Weight
678.81
Precautions
H302, H315, H319
References & Citations
[1]Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12 (10) :2570-2578.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
K3069606 1.0 µg DNA
Speer4a sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
Sign In for Pricing
View Details 
sc-337493 20 mg
A mixture of N- (13-trifluoroacetoxydecosanoyl) -beta-aalanine and N- (14-trifluoroacetoxydecosanoyl) -beta-alanine derived from trans docosenoic acid
Sign In for Pricing
View Details MBS6280048-01 0.2 mL
C7orf28A, ID (CCZ1, C7orf28A, Vacuolar fusion protein CCZ1 homolog) (FITC)
Sign In for Pricing
View Details MBS6280048-02 5x 0.2 mL
C7orf28A, ID (CCZ1, C7orf28A, Vacuolar fusion protein CCZ1 homolog) (FITC)
Sign In for Pricing
View Details