SGC-STK17B-1
SGC-STK17B-1, a chemical probe, is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC50: 34 nM, KD: 5.6 nM) [1].
Product Specifications
CAS Number
[2650530-00-8]
UNSPSC
12352005
Target
DAPK
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sgc-stk17b-1.html
Purity
98.5
Solubility
10 mM in DMSO
Smiles
O=C(CSC1=NC=NC2=C1SC(C3=CC4=C(C=CC=C4)S3)=C2)O
Molecular Formula
C16H10N2O2S3
Molecular Weight
358.46
References & Citations
[1]Picado A, et al. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem. 2020 Dec 10;63 (23) :14626-14646.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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