What is the catalog number for C-Dim 12?

The catalog number for C-Dim 12 is SIH-616-5MG.

What sizes are available for C-Dim 12?

C-Dim 12 is available in the following size(s): 5 mg.

Is C-Dim 12 in stock?

C-Dim 12 is currently made to order / not held in immediate stock. Contact us for lead time.

C-Dim 12

Displays neuroprotective activity in a mouse model of progressive neurodegeneration

Product Specifications

Background

C-DIM 12 is a nurr1 activator that inhibits bladder cancer growth (1,2). It also inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters (3). It displays neuroprotective activity in a mouse Parkinson's disease models (4).

CAS Number

178946-89-9

Product Name Alternative

3,3'-[ (4-Chlorophenyl) methylene]bis[1H-indole]

UNSPSC

41116105

Type

Activator

Source

Synthetic

Field of Research

Purity

>98% (TLC) ; NMR (Conforms)

Weight

0.005

Format

Orange powder

Solubility

May be dissolved in DMSO (35 mg/ml); or ethanol (35 mg/ml)

Molecular Formula

C23H17ClN2

Molecular Weight

356.9

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1.Inamoto T., et al. (2008) Mol. Cancer Ther. 7:3825 2.Li X., et al. (2012) Biochem. Pharmacol. 83:1445 3.De Miranda B.R.,et al. (2015) Mol. Pharmacol. 87:1021 4.De Miranda B.R., et al. (2013) J. Pharmacol. Exp. Ther. 345:125