2BAct
Product Specifications
UNSPSC Description
2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495)[1].
Target Antigen
Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2bact.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(C=N1)=NC=C1C(F)F)NC(C2)(C3)CC23NC(COC(C=C4)=CC(F)=C4Cl)=O
Molecular Weight
440.80
References & Citations
[1]Wong YL, et al. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife. 2019;8:e42940. Published 2019 Jan 9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125021/2BAct-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125021/2BAct-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2143542-28-1
Available Sizes
Curated Selection
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