Anti-Quinidine Mouse Monoclonal Antibody - Library Pack

Anti-Quinidine Mouse Monoclonal Antibody Library Pack - Includes 100 ug of each of the following antibodies:<br><br> 16501 - Anti-Quinidine Mouse Monoclonal Antibody - Clone QD11-228.6.5 - Isotype IgG2b<br> 16502 - Anti-Quinidine Mouse Monoclonal Antibody - Clone QD11-261.3.6 - Isotype IgG1<br> 16503 - Anti-Quinidine Mouse Monoclonal Antibody - Clone QD11-265.2.3 - Isotype IgG1<br> 16504 - Anti-Quinidine Mouse Monoclonal Antibody - Clone QD13-406.6.1 - Isotype IgG1<br> 16505 - Anti-Quinidine Mouse Monoclonal Antibody - Clone QD14-504.5 - Isotype IgG1<br>

Quinidine is a class I antiarrhythmic agent. Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (INa) which causes the phase 0 depolarization of the cardiac action potential to decrease (decreased Vmax). Quinidine also blocks the slowly inactivating, tetrodotoxin-sensitive Na current, the slow inward calcium current (ICa), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito. At micromolar concentrations, quinidine inhibits Na /K -ATPase by binding to the same receptor sites as the digitalis glycosides such as ouabain.