Apoptozole

Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.

Product Specifications

CAS Number

[1054543-47-3]

Product Name Alternative

Apoptosis Activator VII

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HSP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Apoptozole.html

Purity

99.42

Solubility

DMSO : ≥ 100 mg/mL

Smiles

NC(C(C=C1)=CC=C1CN2C(C3=CC=C(OC)C=C3)=C(C4=CC=C(OC)C=C4)N=C2C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O

Molecular Formula

C33H25F6N3O3

Molecular Weight

625.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Williams DR, et al. An apoptosis-inducing small molecule that binds to heat shock protein 70. Angew Chem Int Ed Engl. 2008;47 (39) :7466-9.|[2]Cho HJ, et al. Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis. Mol Biosyst. 2015 Oct;11 (10) :2763-9.|[3]Ko SK, et al. A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities. Chem Biol. 2015 Mar 19;22 (3) :391-403.