N-Arachidonyldopamine

N-Arachidonyldopamine is a potent and selective endogenous CB1 receptor agonist with a Ki of 250 nM[1]. N-Arachidonyldopamine is also a potent and selective TRPV1 agonist an with EC50 of ~ 50 nM[2].

Product Specifications

CAS Number

[199875-69-9]

UNSPSC

12352005

Hazard Statement

H225, H350

Target

Cannabinoid Receptor; TRP Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-arachidonyldopamine.html

Purity

98.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCC1=CC(O)=C(O)C=C1)=O

Molecular Formula

C28H41NO3

Molecular Weight

439.63

Precautions

H225, H350

References & Citations

[1]Bisogno T, et al. N-acyl-dopamines: novel synthetic CB (1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem J. 2000 Nov 1;351 Pt 3 (Pt 3) :817-24.|[2]Huang SM, et al. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci U S A. 2002 Jun 11;99 (12) :8400-5.