VX-11e
VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.
Product Specifications
CAS Number
896720-20-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/VX-11e.html
Purity
98.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=CC(Cl)=C(NC2=NC(C3=CNC(C(N[C@H](CO)C4=CC=CC(Cl)=C4)=O)=C3)=C(C)C=N2)C=C1
Molecular Formula
C24H20Cl2FN5O2
Molecular Weight
500.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Aronov, Alex M., et al. Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control. Journal of Medicinal Chemistry (2009), 52 (20), 6362-6368.|[2]Krepler C, et al. Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies. Clin Cancer Res. 2016 Apr 1;22 (7) :1592-602.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK2
Available Sizes
Frequently Asked Questions
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