VX-11e

VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM.

Product Specifications

CAS Number

[896720-20-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ERK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/VX-11e.html

Purity

98.94

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC1=CC(Cl)=C(NC2=NC(C3=CNC(C(N[C@H](CO)C4=CC=CC(Cl)=C4)=O)=C3)=C(C)C=N2)C=C1

Molecular Formula

C24H20Cl2FN5O2

Molecular Weight

500.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Aronov, Alex M., et al. Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control. Journal of Medicinal Chemistry (2009), 52 (20), 6362-6368.|[2]Krepler C, et al. Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies. Clin Cancer Res. 2016 Apr 1;22 (7) :1592-602.