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Cremophor EL-36

Cremophor EL-36 is a nonionic surfactant, mainly used as a solubilizing carrier for poorly soluble Paclitaxel. The functions of Cremophor EL-36 include: 1) affecting pharmacokinetics by encapsulating drugs in micelles, changing drug distribution and clearance; 2) activating the complement system and inducing allergic reactions; 3) binding to lipoproteins and interfering with lipid metabolism. Cremophor EL-36 increases drug solubility through micellization, while mediating toxicity through complement activation and lipoprotein interactions[1][2].

Product Specifications

CAS Number

61791-12-6

Product Name Alternative

Polyoxyethylene (36) Castor Oil; PEG-36 Castor Oil

UNSPSC

12352200

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cremophor-el-36.html

Solubility

H2O : ≥ 100 mg/mL

Smiles

[CremophorEL-36]

References & Citations

[1]Gelderblom H, et al. Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer. 2001 Sep;37 (13) :1590-8.|[2]Kongshaug M, et al. Interaction of cremophor EL with human plasma. Int J Biochem. 1991;23 (4) :473-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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