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Homobutein

Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4].

Product Specifications

CAS Number

34000-39-0

UNSPSC

12352005

Target

HDAC; NF-κB; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/homobutein.html

Purity

98.35

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C(OC)=C2

Molecular Formula

C16H14O5

Molecular Weight

286.28

References & Citations

[1]Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28 (3) :797-805.|[2]Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20;92 (3) :369-383.|[3]Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov;65 (22) :3029-32.|[4]Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242 (1) : 71-90.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Toxoplasma

Available Sizes

Frequently Asked Questions

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