PDpep1.3

PDpep1.3 is a peptide inhibitor targeting α-synuclein, which disrupts the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B) . This disruption enables PDpep1.3 to restore the degradative functions of endosomes and lysosomes, reducing the levels and aggregation of α-synuclein, and safeguarding dopaminergic neurons from α-synuclein-induced degeneration. PDpep1.3 is useful for research on neurodegenerative diseases and protein-protein interactions.