(S, R, S) -AHPC (monohydrochloride)

(S, R, S) -AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1][2][3].

Product Specifications

CAS Number

[1448189-80-7]

Product Name Alternative

VH032-NH2 (monohydrochloride) ; VHL ligand 1 (monohydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Protein_degrader_1_hydrochloride.html

Purity

99.83

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl

Molecular Formula

C22H31ClN4O3S

Molecular Weight

467.02

Precautions

H302, H315, H319, H335

References & Citations

[1]Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10 (8) :1831-7.|[2]Vu LP, et al. Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers[J]. J Med Chem. 2023 Sep 28;66 (18) :12776-12811. |[3]Krieger J, et al. Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. ChemMedChem. 2023 Apr 17;18 (8) :e202200615.