GR 113808
GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8) . GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors[1].
Product Specifications
CAS Number
144625-51-4
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gr-113808.html
Purity
99.96
Solubility
DMSO : 39 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=CN(C)C2=C1C=CC=C2)OCC3CCN(CCNS(=O)(C)=O)CC3
Molecular Formula
C19H27N3O4S
Molecular Weight
393.50
References & Citations
[1]Gale JD, et al. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.Br J Pharmacol. 1994 Jan;111 (1) :332-8.|[2]Spohn SN, et al.Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.Gastroenterology. 2016 Nov;151 (5) :933-944.e3.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor; Apolipoprotein D; lactoferrin; mLAG-3; α-1 microglobulin
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