Monomethyl lithospermate

Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) [1].

Product Specifications

CAS Number

[933054-33-2]

Product Name Alternative

Lithospermic acid monomethyl ester

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Akt

Type

Natural Products

Related Pathways

PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/monomethyl-lithospermate.html

Solubility

10 mM in DMSO

Smiles

O=C(/C=C/C1=C2C(O[C@@H]([C@H]2C(OC)=O)C3=CC(O)=C(O)C=C3)=C(O)C=C1)O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O

Molecular Formula

C28H24O12

Molecular Weight

552.48

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Yang F, et al. Monomethyl lithospermate alleviates ischemic stroke injury in middle cerebral artery occlusion mice in vivo and protects oxygen glucose deprivation/reoxygenation induced SHSY-5Y cells in vitro via activation of PI3K/Akt signaling. Front Pharmacol. 2022 Oct 13;13:1024439.