Brevianamide F

Brevianamide F (Cyclo (L-Pro-L-Trp) ) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC50 of 4.8 μM[1][2].

Product Specifications

CAS Number

[38136-70-8]

Product Name Alternative

Cyclo (L-Pro-L-Trp)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; PI3K

Type

Natural Products

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Brevianamide-F.html

Purity

99.03

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@H]1CC2=CNC3=C2C=CC=C3)[C@@](CCC4)([H])N4C1=O

Molecular Formula

C16H17N3O2

Molecular Weight

283.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Gos FMWR, et al. Antibacterial Activity of Endophytic Actinomycetes Isolated from the Medicinal Plant Vochysia divergens (Pantanal, Brazil) . Front Microbiol. 2017 Sep 6;8:1642.|[2]Yang ZD, et al. Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla. Curr Microbiol. 2019 Jul;76 (7) :904-908.