BC21
BC21 (NSC 109268) is a β-catenin/Tcf4 inhibitor with an IC50 of 5 μM. BC21 effectively inhibits the binding of β-catenin to Tcf4-derived peptides and suppresses β-catenin/Tcf4-driven reporter gene activity. BC21 can be utilized in cancer research[1].
Product Specifications
CAS Number
691005-38-6
Product Name Alternative
NSC 109268
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bc21.html
Smiles
C12=CC=C3C(C=CC=C3)=C1C[N]4(CCCCC4)[Cu+2]5([O-]2)[Cl-][Cu+2]6([N]7(CCCCC7)CC8=C(C=CC=C9)C9=CC=C8[O-]6)[Cl-]5
Molecular Formula
C32H36Cl2Cu2N2O2
Molecular Weight
678.64
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Tian W, et al. Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction. Biochemistry. 2012 Jan 17;51 (2) :724-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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