BC21

BC21 (NSC 109268) is a β-catenin/Tcf4 inhibitor with an IC50 of 5 μM. BC21 effectively inhibits the binding of β-catenin to Tcf4-derived peptides and suppresses β-catenin/Tcf4-driven reporter gene activity. BC21 can be utilized in cancer research[1].

Product Specifications

CAS Number

[691005-38-6]

Product Name Alternative

NSC 109268

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

β-catenin

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bc21.html

Smiles

C12=CC=C3C(C=CC=C3)=C1C[N]4(CCCCC4)[Cu+2]5([O-]2)[Cl-][Cu+2]6([N]7(CCCCC7)CC8=C(C=CC=C9)C9=CC=C8[O-]6)[Cl-]5

Molecular Formula

C32H36Cl2Cu2N2O2

Molecular Weight

678.64

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Tian W, et al. Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction. Biochemistry. 2012 Jan 17;51 (2) :724-31.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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