TRPV3 antagonist 74a

TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2].

Product Specifications

CAS Number

[1432051-63-2]

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trpv3-antagonist-74a.html

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@H](C1=CC=CC=N1)[C@@]2(C3=CC(C(F)(F)F)=CC=N3)C[C@@](O)(C2)C

Molecular Formula

C17H17F3N2O2

Molecular Weight

338.32

References & Citations

[1]Gomtsyan A, et al. Synthesis and Pharmacology of (Pyridin-2-yl) methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem. 2016;59 (10) :4926-4947.|[2]Zhao J, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol. 2020;140 (8) :1524-1532.