BI 639667
BI 639667 (compound 19n), a chemical probe, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay[1].
Product Specifications
CAS Number
[1295298-26-8]
Product Name Alternative
CCR1 antagonist 8
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/bi-639667.html
Purity
98.87
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C(C1=CN=CC2=C1C=NN2C3=CC=C(F)C=C3)NC4(C5=CC(S(=O)(C)=O)=NC=C5)CC4
Molecular Formula
C22H18FN5O3S
Molecular Weight
451.47
References & Citations
[1]Harcken C, et al. Identification of novel azaindazole CCR1 antagonist clinical candidates. Bioorg Med Chem Lett. 2019 Feb 1;29 (3) :441-448.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CCR1
Available Sizes
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