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GDC-0927

GDC-0927 (SRN-927) is a potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist[1].

Product Specifications

CAS Number

[1642297-01-5]

Product Name Alternative

SRN-927

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GDC-0927.html

Purity

99.98

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

OC1=CC=C2C(C(C)=C(C3=CC=CC(O)=C3)[C@H](C4=CC=C(OCCN5CC(CF)C5)C=C4)O2)=C1

Molecular Formula

C28H28FNO4

Molecular Weight

461.52

Precautions

H302, H315, H319, H335

References & Citations

[1]MN Dickler, et al. Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive (ER+) HER2-negative metastatic breast cancer (BC) . AACR; Cancer Res 2018;78 (4 Suppl) :Abstract nr PD5-10.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

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