Bestatin (hydrochloride)
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N) /APN and leukotriene A4 hydrolase, used for cancer research.
Product Specifications
CAS Number
65391-42-6
Product Name Alternative
Ubenimex hydrochloride
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aminopeptidase; Antibiotic; Bacterial
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Bestatin-hydrochloride.html
Purity
99.94
Solubility
DMSO : 233.33 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O.Cl
Molecular Formula
C16H25ClN2O4
Molecular Weight
344.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Hossain A, et al. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 Aug;149:100-6|[2]Qian X, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2016 May-Jun;23 (3) :e680-9.|[3]Lis M, et al. The effects of bestatin on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice. Immunopharmacol Immunotoxicol. 2013 Feb;35 (1) :133-8|[4]Poloz Y, et al. Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum. Eukaryot Cell. 2012 Apr;11 (4) :545-57
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
CD13
Available Sizes
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