JSH-150
JSH-150 is a highly selective and potent CDK9 inhibitor with an IC50 of 1 nM.
Product Specifications
CAS Number
[2247481-21-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/JSH-150.html
Purity
98.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COCCN[C@@H]1CC[C@@H](NC2=NC=C(Cl)C(C3=CSC(NCC4(C#N)CCOCC4)=N3)=C2)CC1
Molecular Formula
C24H33ClN6O2S
Molecular Weight
505.08
Precautions
H302, H315, H319, H335
References & Citations
[1]Beilei Wang, et al. Discovery of 4- (((4- (5-chloro-2- (((1s,4s) -4- ((2-methoxyethyl) amino) cyclohexyl) amino) pyridin-4-yl) thiazol-2-yl) amino) methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor. Eur J Med Chem. 13 September 2018.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK14; CDK16; CDK2; CDK5; CDK7; CDK9
Available Sizes
Curated Selection
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