Lw13

Lw13 is a Hsp90-targeting PROTAC and achieves maximum degradation at a concentration of 0.05 μM in Siha cells. Lw13 induces cell apoptosis and exhibits potent anti-tumor activity both in vitro and in vivo (Sturcture Note: (Blue: Cereblon ligand (HY-A0003), Black: linker; Pink: Hsp90 inhibitor SNX-5422 (HY-10213) ) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; HSP; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lw13.html

Smiles

O=C(N)C1=C(N[C@@H]2CC[C@@H](OC(CNC(CCCCCCCNC3=C4C(C(N(C5CCC(NC5=O)=O)C4)=O)=CC=C3)=O)=O)CC2)C=C(N6N=C(C(F)(F)F)C7=C6CC(C)(C)CC7=O)C=C1

Molecular Formula

C46H55F3N8O8

Molecular Weight

904.97

References & Citations

[1]Liang J, et al . Novel Hsp90-Targeting PROTACs: Enhanced synergy with cisplatin in combination therapy of cervical cancer. Eur J Med Chem. 2024 Sep 5;275:116572.