VU0090157

VU0090157 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR) . VU0090157 increases the affinity of ACh by binding to the allosteric site. VU0090157 can be used in the study of schizophrenia and Alzheimer's disease[1].

Product Specifications

CAS Number

[312622-77-8]

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0090157.html

Smiles

O=C(OC1CCCC1)C2=C(N(C(NC2C3=C(C=C4OCOC4=C3)[N+]([O-])=O)=O)C)C

Molecular Formula

C19H21N3O7

Molecular Weight

403.39

References & Citations

[1]Marlo J E, et al. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity[J]. Molecular pharmacology, 2009, 75 (3) : 577-588.