VU0090157
Product Specifications
UNSPSC Description
VU0090157 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR). VU0090157 increases the affinity of ACh by binding to the allosteric site. VU0090157 can be used in the study of schizophrenia and Alzheimer's disease[1].
Target Antigen
mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0090157.html
Smiles
O=C(OC1CCCC1)C2=C(N(C(NC2C3=C(C=C4OCOC4=C3)[N+]([O-])=O)=O)C)C
Molecular Weight
403.39
References & Citations
[1]Marlo J E, et al. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity[J]. Molecular pharmacology, 2009, 75(3): 577-588.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128783/VU0090157-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128783/
Clinical Information
No Development Reported
CAS Number
312622-77-8
Curated Selection
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