VU0090157
VU0090157 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR) . VU0090157 increases the affinity of ACh by binding to the allosteric site. VU0090157 can be used in the study of schizophrenia and Alzheimer's disease[1].
Product Specifications
CAS Number
312622-77-8
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0090157.html
Smiles
O=C(OC1CCCC1)C2=C(N(C(NC2C3=C(C=C4OCOC4=C3)[N+]([O-])=O)=O)C)C
Molecular Formula
C19H21N3O7
Molecular Weight
403.39
References & Citations
[1]Marlo J E, et al. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity[J]. Molecular pharmacology, 2009, 75 (3) : 577-588.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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