Colesevelam (hydrochloride)

Colesevelam (hydrochloride) is a bile acid sequestrant that bind bile acids in the gut. Colesevelam (hydrochloride) inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduced cholesterol levels in patients with cholestatic pruritus and Crohn’s disease.

Product Specifications

CAS Number

[182815-44-7]

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/colesevelam-hydrochloride.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

[Colesevelam(hydrochloride)]

Molecular Formula

(C3H8NCl) 2. (C9H20N2OCl2) . (C13H28NCl) 7. (C12H28N2Cl2) 6

Molecular Weight

3694.64

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Potthoff MJ, Potts A, He T, et al. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol. 2013;304 (4) :G371-G380. |[2]Cabré N, Duan Y, Llorente C, et al. Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice. Cells. 2021;10 (6) :1496.