8-iso Prostaglandin F3α

8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 μM.

Product Specifications

CAS Number

[7045-31-0]

Product Name Alternative

8-epi PGF3α; 8-iso PGF3α

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/8-iso-prostaglandin-f3α.html

Smiles

O[C@@H]1[C@H]([C@H]([C@@H](C1)O)/C=C/[C@H](C/C=C\CC)O)C/C=C\CCCC(O)=O

Molecular Formula

C20H32O5

Molecular Weight

352.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Praticò, et al. Local amplification of platelet function by 8-epi prostaglandin F2α is not mediated by thromboxane receptor isoforms. J. Biol. Chem. 271 (25), 14916-14924 (1996) .