Bitopertin

Bitopertin is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.

Product Specifications

CAS Number

[845614-11-1]

Product Name Alternative

RG1678; RO4917838

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Bitopertin.html

Purity

99.90

Solubility

DMSO : ≥ 50 mg/mL

Smiles

FC1=CC(C(F)(F)F)=CN=C1N2CCN(C(C3=CC(S(=O)(C)=O)=CC=C3O[C@H](C(F)(F)F)C)=O)CC2

Molecular Formula

C21H20F7N3O4S

Molecular Weight

543.46

Precautions

H302, H315, H320, H335

References & Citations

[1]Alberati D, et al. Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia. Neuropharmacology. 2012 Feb;62 (2) :1152-61.|[2]Pinard E, et al. Selective GlyT1 Inhibitors: Discovery of [4- (3-Fluoro-5-trifluoromethylpyridin-2-yl) piperazin-1-yl][5-methanesulfonyl-2- ((S) -2,2,2-trifluoro-1-methylethoxy) phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia. J Me