SMART1
SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models. (Blue: CRBN ligand; Black: linker; Pink: Smurf1 ligand (Smurf1-L) ) [1].
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; PDK-1; PROTACs
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smart1.html
Purity
99.87
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CNC(C1=NC=CC(OC2=CC=C(C=C2)N3C=C(N=N3)C4=CC(NC(C5CCCN(C5)C6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O)=CC=C4)=C1)=O
Molecular Formula
C40H35N9O7
Molecular Weight
753.76
Precautions
H302, H315, H319, H335
References & Citations
[1]Peng Z, et al. Targeting Smurf1 to block PDK1-Akt signaling in KRAS-mutated colorectal cancer. Nat Chem Biol. 2024 Jul 22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
C7orf34 Polyclonal Antibody, Cy5.5 Conjugated
ENO4, ID (ENO4, C10orf134, Enolase-like protein ENO4) (MaxLight 405) discontinued
