RVG29-Cys

RVG29-Cys is a peptide derived from rabies virus glycoprotein (RVG) that specifically binds to nicotinic acetylcholine receptors (nAchR) on neural cells. It is employed to functionalize lipid nanoparticles (LNPs) via thiol-maleimide click chemistry for targeting nAchR present on the blood-brain barrier (BBB) . mRNA LNPs functionalized with RVG29-Cys demonstrate enhanced transfection efficiency in cultured brain endothelial and neuronal cells, as well as in mice following systemic administration.