Phosphonoacetic acid

Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit HSV DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins[1][2].

Product Specifications

CAS Number

[4408-78-0]

UNSPSC

12352211

Hazard Statement

H314

Target

DNA/RNA Synthesis; Endogenous Metabolite; HSV; Orthopoxvirus

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/phosphonoacetic-acid.html

Purity

98.0

Solubility

H2O : 260 mg/mL (ultrasonic)

Smiles

O=C(O)CP(O)(O)=O

Molecular Formula

C2H5O5P

Molecular Weight

140.03

Precautions

H314

References & Citations

[1]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52. |[2]Honess RW, et al. Herpes simplex virus resistance and sensitivity to phosphonoacetic acid. J Virol. 1977 Feb;21 (2) :584-600.