SI-2

SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) [1].

Product Specifications

CAS Number

[223788-33-8]

Product Name Alternative

EPH 116

UNSPSC

12352005

Target

Apoptosis; Src

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/si-2.html

Smiles

CN1C(N/N=C(C)/C2=CC=CC=N2)=NC3=CC=CC=C13

Molecular Formula

C15H15N5

Molecular Weight

265.31

References & Citations

[1]Song X, et al., Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 3;113 (18) :4970-5.