SI-2
SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) [1].
Product Specifications
CAS Number
223788-33-8
Product Name Alternative
EPH 116
UNSPSC
12352005
Target
Apoptosis; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/si-2.html
Smiles
CN1C(N/N=C(C)/C2=CC=CC=N2)=NC3=CC=CC=C13
Molecular Formula
C15H15N5
Molecular Weight
265.31
References & Citations
[1]Song X, et al., Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 3;113 (18) :4970-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15165325 1 Vial
Lentiviral mouse Hspb8 shRNA (UAS) - Lentiviral mouse Hspb8 shRNA (UAS, RFP) plasmid
Sign In for Pricing
View Details 
46380151 3x 1.0 µg DNA
TCF23 CRISPR All-in-one AAV vector set (with saCas9)(Human)
Sign In for Pricing
View Details 