SI-2
SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) [1].
Product Specifications
CAS Number
[223788-33-8]
Product Name Alternative
EPH 116
UNSPSC
12352005
Target
Apoptosis; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/si-2.html
Smiles
CN1C(N/N=C(C)/C2=CC=CC=N2)=NC3=CC=CC=C13
Molecular Formula
C15H15N5
Molecular Weight
265.31
References & Citations
[1]Song X, et al., Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 3;113 (18) :4970-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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