SMIP34
SMIP34 is a PELP1 inhibitor. SMIP34 binds to PELP1 with a Kd of 37.4 μM. SMIP34 inhibits cancer cell proliferation and tumor progression. SMIP34 can be used for breast cancer research, and is active against wild-type (WT), mutant (MT) ER+ and therapy-resistant (TR) -ER+ breast cancer[1].
Product Specifications
CAS Number
1189710-20-0
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smip34-6.html
Purity
90.0
Smiles
O=C(C1=NN2C(C(N(C(C)(C2)C(NC3CCCC3)=O)CCCC)=O)=C1)NC4=CC=C(C)C(Cl)=C4
Molecular Formula
C25H32ClN5O3
Molecular Weight
486.01
References & Citations
[1]Altwegg KA, et al. A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer. Cancer Res. 2022 Oct 17;82 (20) :3830-3844.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Dedicated for Diverse Library
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) (PAPPA/2715), CF488A conjugate, 0.1mg/mL
![FITC Anti-Human CD2 Antibody[TS1/8]](https://cdn.genprice.uk/products/763/68dd14af061270361e7d39af/imageurl/e-ab-f1148c.webp)