N-Acetyl-Ser-Asp-Lys-Pro (acetate)

N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE) . N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties[1][2].

Product Specifications

Product Name Alternative

Ac-SDKP (acetate)

UNSPSC

12352209

Target

Angiotensin-converting Enzyme (ACE)

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-acetyl-ser-asp-lys-pro-acetate.html

Purity

99.88

Solubility

DMSO : 5.83 mg/mL (ultrasonic)

Smiles

O=C([C@@H](CC(O)=O)NC([C@H](CO)NC(C)=O)=O)N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(O)=O)=O.CC(O)=O

Molecular Formula

C22H37N5O11

Molecular Weight

547.56

References & Citations

[1]Peng H, et al. Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension. Hypertension. 2003;42 (6) :1164-1170.|[2]Sharma U, et al. Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol. 2008;294 (3) :H1226-H1232.