DBCO-PEG2-NHS ester
Product Specifications
UNSPSC Description
DBCO-PEG2-NHS ester is a click chemistry reagent containing an azide group. DBCO-PEG2-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only[1].
Target Antigen
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dbco-peg2-nhs-ester.html
Solubility
10 mM in DMSO
Smiles
O=C(CCOCCOCCNC(CCC(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)=O)=O)ON4C(CCC4=O)=O
Molecular Weight
561.58
References & Citations
[1]Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151827/DBCO-PEG2-NHS-ester-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151827/DBCO-PEG2-NHS-ester-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2585653-12-7
Available Sizes
Curated Selection
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