NS6180
NS6180 is a new orally active KCa3.1 channel inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC50value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) [1].
Product Specifications
CAS Number
353262-04-1
UNSPSC
12352005
Hazard Statement
H317, H411
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/NS6180.html
Purity
99.76
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1CSC2=CC=CC=C2N1CC3=CC=CC(C(F)(F)F)=C3
Molecular Formula
C16H12F3NOS
Molecular Weight
323.34
Precautions
H317, H411
References & Citations
[1]Strobak D, et al. NS6180, a new K (Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br J Pharmacol. 2013 Jan;168 (2) :432-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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