NS6180
NS6180 is a new orally active KCa3.1 channel inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC50value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) [1].
Product Specifications
CAS Number
[353262-04-1]
UNSPSC
12352005
Hazard Statement
H317, H411
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/NS6180.html
Purity
99.76
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1CSC2=CC=CC=C2N1CC3=CC=CC(C(F)(F)F)=C3
Molecular Formula
C16H12F3NOS
Molecular Weight
323.34
Precautions
H317, H411
References & Citations
[1]Strobak D, et al. NS6180, a new K (Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br J Pharmacol. 2013 Jan;168 (2) :432-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6385519-01 0.1 mL
MKNK1 (MAP Kinase-interacting Serine/Threonine-protein Kinase 1, MAP Kinase Signal-integrating Kinase 1, MAPK Signal-integrating Kinase 1) (MaxLight 650)
Ask
View Details 
MBS6385519-02 5x 0.1 mL
MKNK1 (MAP Kinase-interacting Serine/Threonine-protein Kinase 1, MAP Kinase Signal-integrating Kinase 1, MAPK Signal-integrating Kinase 1) (MaxLight 650)
Ask
View Details 127880-ML405 100 µL
HIST2H2BE (H2BFQ, Histone H2B Type 2-E, Histone H2B-GL105, Histone H2B.q, H2B, MGC119802, MGC119804, MGC129733, MGC129734) (MaxLight 405) discontinued
Ask
View Details MBS6333547-01 0.1 mL
PI3KC3 (S282) (Phosphatidylinositol 3-kinase catalytic subunit type 3, PtdIns-3-kinase type 3, PI3-kinase type 3, PI3K type 3, Phosphoinositide-3-kinase class 3, Phosphatidylinositol 3-kinase p100 subunit, vps34) (MaxLight 490)
Ask
View Details