PI3Kδ-IN-16
PI3Kδ-IN-16 is a potent and selective PI3Kδ inhibitor with an IC50 value of 0.9 nM. PI3Kδ-IN-16 has a strong anti-proliferative effect on SU-DHL-6 cells, causing cell cycle arrest and inducing apoptosis. PI3Kδ-IN-16 tightly bins to PI3Kδ protein with a planar-shaped conformation. The kinase activity of PI3Kδ-IN-16 which is ~378-fold over PI3Kα, 412-fold over PI3Kβ, and 10-fold over PI3Kγ. PI3Kδ-IN-16 can be used for the study of hematologic malignancies[1].
Product Specifications
CAS Number
[2766437-35-6]
UNSPSC
12352005
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kδ-in-16.html
Purity
99.02
Solubility
DMSO : 76.92 mg/mL (ultrasonic; adjust pH to 7 with 1 M HCl)
Smiles
COC1=NC=C(C2=CC3=C(N=CN=C3N[C@@H](C)C(N4CCN(C)CC4)=O)C=C2)C=C1
Molecular Formula
C22H26N6O2
Molecular Weight
406.48
References & Citations
[1]Lei H, et al. Discovery of potent and selective PI3Kδ inhibitors bearing amino acid fragments. Bioorg Chem. 2023 Sep;138:106594.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Available Sizes
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