What is the catalog number for Ajugol?

The catalog number for Ajugol is HY-N0914.

What sizes are available for Ajugol?

Ajugol is available in the following size(s): 1 mg, 5 mg, 10 mM - 1 mL, 10 mg.

How many pack sizes does Ajugol come in?

Ajugol is available in 4 different pack sizes.

Ajugol is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Ajugol?

Ajugol is manufactured by QuantiMol.

What is the estimated delivery time for Ajugol?

Estimated delivery time for Ajugol is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Ajugol?

The safety data sheet for Ajugol is available here: http://file.medchemexpress.com/batch_PDF/HY-N0914/Ajugol-SDS-MedChemExpress.pdf.

Ajugol

Ajugol is an orally active iridoid glycoside found in the traditional Chinese medicine Leonurus japonicus. Ajugol is an autophagy activator. Ajugol activates TFEB-mediated autophagy and lysosomal biogenesis. Ajugol also has anti-inflammatory effects. Ajugol has great potential in the research of asthma, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis[1][2][3][4].

Product Specifications

CAS Number

52949-83-4

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; Interleukin Related; mTOR; Parasite; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Ajugol.html

Purity

99.61

Solubility

DMSO : ≥ 3.7 mg/mL

Smiles

O[C@H]1[C@](O[C@H](CO)[C@@H](O)[C@@H]1O)([H])O[C@H](OC=C2)[C@@]3([H])[C@]2([H])[C@H](O)C[C@@]3(O)C

Molecular Formula

C15H24O9

Molecular Weight

348.35

Precautions

H302

References & Citations

[1]Deniz Tasdemir, et al. Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots. Phytochemistry. 2005 Feb;66 (3) :355-62.|[2]Wu J, et al. Ajugol's upregulation of TFEB-mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model. Chin Med. 2023 Sep 7;18 (1) :113.|[3]Zhang H, et al. Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease. Pharmacol Res. 2021 Dec;174:105964.|[4]Yi L, et al.A novel iridoid glycoside leonuride (ajugol) attenuates airway inflammation and remodeling through inhibiting type-2 high cytokine/chemokine activity in OVA-induced asthmatic mice. Phytomedicine. 2022 Oct;105:154345.|[5]Xue B, et al. Pharmacokinetics and tissue distribution of Aucubin, Ajugol and Catalpol in rats using a validated simultaneous LC-ESI-MS/MS assay. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:245-53.