4-Nitropyrazole

4-Nitropyrazole is a five-membered nitrogen-containing heterocyclic compound that can be used as a drug intermediate. 4-Nitropyrazole can be synthesized into antibiotics/antifungal/antiviral agents containing pyrazole rings. 4-Nitropyrazole is synthesized through C-H activation reactions to produce LRRK2 inhibitors, which are used in the research of Parkinson's disease[1][2][3].

Product Specifications

CAS Number

[2075-46-9]

UNSPSC

12352200

Hazard Statement

H302, H318

Target

Drug Intermediate

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-nitropyrazole.html

Purity

99.99

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=[N+](C1=CNN=C1)[O-]

Molecular Formula

C3H3N3O2

Molecular Weight

113.08

Precautions

H302, H318

References & Citations

[1]Manfredini S, et al. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides. J Med Chem. 1992 Mar 6;35 (5) :917-24. |[2]Barron B, et al. A Concise Enantioselective Synthesis of Fluorinated Pyrazolo-Piperidine GSK3901383A Enabled by an Organocatalytic Aza-Michael Addition. Org Lett. 2024 Mar 1;26 (8) :1533-1538. |[3]Hrelia P, et al. Synthesis, metabolism and structure-mutagenicity relationships of novel 4-nitro- (imidazoles and pyrazoles) in Salmonella typhimurium. Mutat Res. 1998 Feb 2;397 (2) :293-301.