Cynomolgus Integrin alpha 6 beta 4 (ITGA6&ITGB4) Heterodimer Protein, His Tag&Tag Free (MALS verified)
Integrin α6β4 is a key laminin receptor predominantly found in stratified squamous epithelia, especially localized to hemidesmosomes in the basal epidermal layer, where it plays a crucial role in cell-basement membrane adhesion, regulation of keratinocyte motility and polarity, and contributes to the structure of hemidesmosomal plaques, distinguishing it from other integrins.
Product Specifications
Expression Region
Phe 24 - Gly 1012 (ITGA6) & Asn 28 - Ser 711 (ITGB4)
Reactivity
Monkey
Conjugation
Unconjugated
Tag
C-10xHis | Native
Field of Research
Immunology & Inflammation
Endotoxin
1.0 EU per μg
Purity
90%
Form
Powder
Molecular Weight
116.8 kDa (ITGA6) & 82 kDa (ITGB4)
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
Cynomolgus ITGA6&ITGB4 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA6 and ITGB4, has a calculated MW of 116.8 kDa (ITGA6) & 82 kDa (ITGB4) . Subunit ITGA6 is fused with flag tag at the C-terminus and subunit ITGB4 contains no tag. The protein migrates as 110-130 kDa (ITGA6) and 90-95 kDa (ITGB4) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Accession Number
ITGA6, A0A2K5WLQ4, ITGB4, A0A2K5TWI7
Preservative
50 mM Tris, 150 mM NaCl, 0.2 M Arginine, pH 7.5
Available Sizes
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