WNK-IN-11
WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.
Product Specifications
CAS Number
[2123489-30-3]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Ser/Thr Protease; WNK Kinase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/WNK-IN-11.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C2=CSC(NC)=N2)=NC=C1Cl)N3CCN(CC4=CC=C(Cl)C=C4)CC3
Molecular Formula
C21H21Cl2N5OS
Molecular Weight
462.40
Precautions
H315, H319, H320
References & Citations
[1]Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60 (16) :7099-7107.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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