WNK-IN-11

WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.

Product Specifications

CAS Number

[2123489-30-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Ser/Thr Protease; WNK Kinase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/WNK-IN-11.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C2=CSC(NC)=N2)=NC=C1Cl)N3CCN(CC4=CC=C(Cl)C=C4)CC3

Molecular Formula

C21H21Cl2N5OS

Molecular Weight

462.40

Precautions

H315, H319, H320

References & Citations

[1]Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60 (16) :7099-7107.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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